Platelets are anucleated blood cells well-known for their critical role in hemostasis, i.e. the prevention of blood loss at sites of mechanical vessel injury. Over the last few decades, platelets have emerged as master orchestrators of inflammatory processes that go beyond hemostasis by interacting and communicating with leukocytes and inflamed vessel walls.
Our group investigates the contribution of platelets and their numerous activation pathways to vascular and inflammatory diseases. Our current projects are particularly focused on deciphering platelet mechanisms in intracranial aneurysms and abdominal aortic aneurysms. We employ multidisciplinary approaches ranging from biochemistry and cell biology to cutting-edge preclinical mouse models coupled with intravital microscopy to tackle these important clinical problems.